Occupational exposure to ethylenebisdithiocarbamates in agriculture and allergy: results from the EUROPIT field study
Articolo
Data di Pubblicazione:
2008
Citazione:
Occupational exposure to ethylenebisdithiocarbamates in agriculture and allergy: results from the EUROPIT field study / G. Swaen, L. van Amelsvoort, D. Boers, E. Corsini, S. Fustinoni, T. Vergieva, C. Bosetti, S. Pennanen, J. Liesivuori, C. Colosio, H. van Loveren. - In: HUMAN & EXPERIMENTAL TOXICOLOGY. - ISSN 0960-3271. - 27:9(2008 Sep), pp. 715-720.
Abstract:
This epidemiological study was carried out to evaluate the possible association
between occupational exposure to ethylenebisdithiocarbamates (EDBC) and allergy.
The study was conducted in four countries in the European Union: The Netherlands,
Finland, Italy and Bulgaria. A total of 248 workers exposed to EDBC and 231
non-occupationally exposed subjects entered the study. Exposure to EDBC was
measured as urinary ethylenethiourea (ETU) in urinary samples collected at
baseline and after 30 days of exposure. Several effect parameters were evaluated
including questionnaire data on allergy, Phadiatop, a general allergy test, and
specific IgE parameters. These data were also collected at baseline and after 30
days of exposure. Cross-sectional as well as longitudinal comparisons were made,
adjusted for potential confounding factors. No association was found between
exposure status, EDBC levels and allergic contact dermatitis, allergic rhinitis,
food allergy or atopy as measured by the Phadiatop. The prevalence of skin
irritation was elevated in the Dutch field study only and is more likely a result
of plant contact rather than EDBC exposure. Occupational exposure to sunlight was
noted to have a protective effect on atopy in terms of IgE positivity. We
conclude that the EDBC exposure levels experienced in our field study are not
associated with increased prevalence of allergic symptoms or allergy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Allergy; Epidemiology; Ethylenebisdithiocarbamate pesticides; Fungicides; Immunotoxicity; Occupational exposure
Elenco autori:
G. Swaen, L. van Amelsvoort, D. Boers, E. Corsini, S. Fustinoni, T. Vergieva, C. Bosetti, S. Pennanen, J. Liesivuori, C. Colosio, H. van Loveren
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