Data di Pubblicazione:
2008
Citazione:
The SLC6/NSS family members KAAT1 and CAATCH1 have weak chloride dependence / S. Bettè, M. Castagna, E. Bossi, A. Peres, V.F. Sacchi. - In: CHANNELS. - ISSN 1933-6950. - 2:5(2008), pp. 358-362.
Abstract:
KAAT1 and CAATCH1 are amino acid transporters cloned from the intestine of the lepidoptera Manduca sexta.(1,2) They are members of the SLC6/NSS family, which groups membrane proteins that use Na+, K+ and Cl- gradients for the coupled transport of amines and amino acids. The report of the atomic-resolution x-ray crystal structure of the eubacterium Aquifex aeolicus leucine transporter (AaLeuT)(3) has contributed significantly to understanding of the structure-function relationship in NSS proteins. Transport by AaLeuT is Cl- independent, whereas many neurotransmitter: sodium symporters like serotonin transporter (SERT), GABA transporter (GAT1), dopamine transporter and norephinephrine transporter, among others, are strongly Cl- dependent.(4)
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Amino acid transport; CAATCH1; Chloride-dependence; KAAT1; Structure/function
Elenco autori:
S. Bettè, M. Castagna, E. Bossi, A. Peres, V.F. Sacchi
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