Combined plasma levels of IL-10 and testosterone, but not soluble HLA-G5, predict the risk of death in COVID-19 patients
Articolo
Data di Pubblicazione:
2023
Citazione:
Combined plasma levels of IL-10 and testosterone, but not soluble HLA-G5, predict the risk of death in COVID-19 patients / G. Amodio, P. Capogrosso, M. Pontillo, M. Tassara, L. Boeri, C. Carenzi, D. Cignoli, A.M. Ferrara, G.A. Ramirez, C. Tresoldi, M. Locatelli, L. Santoleri, A. Castagna, A. Zangrillo, F. De Cobelli, M. Tresoldi, G. Landoni, P. Rovere-Querini, F. Ciceri, F. Montorsi, A. Salonia, S. Gregori. - In: ANDROLOGY. - ISSN 2047-2919. - 11:1(2023), pp. 32-44. [10.1111/andr.13334]
Abstract:
BackgroundThe identification of biomarkers correlated with coronavirus disease 2019 (COVID-19) outcomes is a relevant need for clinical management. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by elevated interleukin (IL)-6, IL-10, HLA-G, and impaired testosterone production. ObjectivesWe aimed at defining the combined impact of sex hormones, interleukin-10, and HLA-G on COVID-19 pathophysiology and their relationship in male patients. Materials and methodsWe measured by chemiluminescence immunoassay, electrochemiluminescent assays, and enzyme-linked immunosorbent assay circulating total testosterone, 17 beta-estradiol (E-2), IL-10, and -HLAG5 as well as SARS-CoV-2 S1/S2 Immunoglobulin G from 292 healthy controls and 111 COVID-19 patients with different disease severity at hospital admission, and in 53 COVID-19 patients at 7-month follow-up. Results and discussionWe found significantly higher levels of IL-10, HLA-G, and E-2 in COVID-19 patients compared to healthy controls and an inverse correlation between IL-10 and testosterone, with IL-10, progressively increasing and testosterone progressively decreasing with disease severity. This correlation was lost at the 7-month follow-up. The risk of death in COVID-19 patients with low testosterone increased in the presence of high IL-10. A negative correlation between SARS-CoV-2 Immunoglobulin G and HLA-G or IL-10 at hospitalization was observed. At the 7-month follow-up, IL-10 and testosterone normalized, and HLA-G decreased. ConclusionOur findings indicate that combined evaluation of IL-10 and testosterone predicts the risk of death in men with COVID-19 and support the hypothesis that IL-10 fails to suppress excessive inflammation by promoting viral spreading.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
COVID-19; HLA-G; IL-10; SARS-CoV-2; male; testosterone
Elenco autori:
G. Amodio, P. Capogrosso, M. Pontillo, M. Tassara, L. Boeri, C. Carenzi, D. Cignoli, A.M. Ferrara, G.A. Ramirez, C. Tresoldi, M. Locatelli, L. Santoleri, A. Castagna, A. Zangrillo, F. De Cobelli, M. Tresoldi, G. Landoni, P. Rovere-Querini, F. Ciceri, F. Montorsi, A. Salonia, S. Gregori
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