Copper(I)-catalysed reaction of hydrazonyl chlorides with homopropargylic alcohols : regioselective synthesis of 5-substituted pyrazoles
Articolo
Data di Pubblicazione:
2022
Citazione:
Copper(I)-catalysed reaction of hydrazonyl chlorides with homopropargylic alcohols : regioselective synthesis of 5-substituted pyrazoles / G. Molteni, A. Silvani, M. Manenti. - In: SYNTHESIS. - ISSN 0039-7881. - (2022 Nov 28). [Epub ahead of print] [10.1055/s-0042-1751770]
Abstract:
Fully regioselective synthesis of 5-hydroxyethylpyrazoles was exploited by reacting hydrazonoyl chlorides with homopropargylic alcohols in the presence of catalytic amounts of copper(I) chloride. Good yields of pyrazolic products and mild reaction conditions were experienced notwithstanding the known, poor reactivity of homopropargylic alcohols towards hydrazonoyl chlorides. The role of copper(I) ion and some mechanistic insights for the formation of reaction products are also discussed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
hydrazonoyl chlorides; copper(I) catalysis; homopropargylic alcohols; pyrazoles; regioselective synthesis
Elenco autori:
G. Molteni, A. Silvani, M. Manenti
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