Development of a novel approach to overcome biofilm formation by natural product derivatives

With the aim to prevent biofilm formation, and based on our previous studies, 1, 2 we explored new strategies involving inorganic nanoparticles for surface covering. In detail, we investigated the functionalization of silica nanoparticles with natural derivatives showing anti-biofilm properties, using linkers of different nature and length. After their analytical characterization, the new derivatives were used to obtain glass coverslips by spin-coating technology for the biological testing (Figure 1). The promising results towards E. coli and P. aeruginosa will be presented. 1 C. Cattò; S. Dell'Orto; F. Villa; S. Villa; A. Gelain; A. Vitali; V. Marzano; S. Baroni S; F. Forlani; F. Cappitelli. PLoS ONE 2015, 10(7), e0131519. 2 C. Cattò; G. Grazioso; S. Dell’Orto; A. Gelain; S. Villa, V. Marzano; A. Vitali; F. Villa; F. Cappitelli; F. Forlani. Biofouling 2017, 33, 235-251