Data di Pubblicazione:
2021
Citazione:
Functionalized nanoparticles as potential antibiofilm agents / A. Gelain, M. Mori, F. Meneghetti, P. Molino, P. Hayes, S. Villa. ((Intervento presentato al 13. convegno International Symposium on Pharmaceutical Sciences tenutosi a Ankara nel 2021.
Abstract:
OP053: FUNCTIONALIZED
NANOPARTICLES AS POTENTIAL
ANTIBIOFILM AGENTS
1Gelain, A., 1Mori, M., 1Meneghetti, F., 2,3Molino,
P., 2,3Hayes, P., 1Villa, S.
1 University of Milan, Faculty of Pharmacy,
Pharmaceutical Sciences Department, Milan, Italy,
arianna.gelain@unimi.it, matteo.mori@unimi.it,
fiorella.meneghetti@unimi.it,
stefania.villa@unimi.it
2 University of Wollongong, AIIM Faculty, Intelligent
Polymer Research Institute, Wollongong, Australia
3 Australian National Fabrication Facility (Materials
Node), University of Wollongong, Wollongong,
pmolino@uow.edu.au, phayes@uow.edu.au
Introduction: Although some bacterial biofilms
could be beneficial to human health (e.g. human
microbiome), it is known that they are also
recognized as one of the main pathogenesis
factors in the development of chronic infectious
processes. Their growth can be prevented through
surface modification by hindering bacterial
adhesion or by inhibiting the development of
bacterial microcolonies, using antibiofilm agents
(passive or active coating). The aim of our research
was the covalent functionalization of nanoparticles
with natural derivatives that, previously used to
obtain new materials (1), have shown interesting
antibiofilm properties (2), limiting the problems
related to existing coatings.
Materials and Methods: Ludox HS-40 colloidal
silica was selected for the functionalization,
considering its potential to be used as coating on
different types of surfaces. The compounds used
to functionalize Ludox HS-40, through suitable
linkers (differing for nature and length), were
salicylic and cinnamic acids derivatives (Figure 1).
The obtained nanoparticles were characterized by
means of qualitative analyses (FT-IR and Raman)
to verify the functionalization of the new
nanoparticles and quantitative analyses (TGA,
XPS) to assess the degree of nanoparticles
functionalization.
Figure 1. Schematic representation of novel
functionalized Ludox HS-40 nanoparticles
Results: The analytical data confirmed that the
functionalization procedures occurred correctly
both in the final derivatives and in the various
intermediates.
Conclusions: These novel nanoparticles could
provide long-term protection from biofilm growth
and reduce the risk of developing resistant strains.
References:
1.Cattò et al., (2015), Plos One, 10:1-24.
2.Cattò et al., (2017), Biofouling, 33:235-251.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Keywords:
nanoparticles; antibiofilm
Elenco autori:
A. Gelain, M. Mori, F. Meneghetti, P. Molino, P. Hayes, S. Villa
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