Data di Pubblicazione:
2021
Citazione:
Morpholino-based peptide oligomers: Synthesis and DNA binding properties / A. Contini, E. Erba, V. Bondavalli, A. Barbiroli, M.L. Gelmi, A. Romanelli. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 549(2021 Apr 16), pp. 8-13. [10.1016/j.bbrc.2021.02.087]
Abstract:
The chemical structure of oligonucleotide analogues dictates the conformation of oligonucleotide analogue oligomers, their ability to hybridize complementary DNA and RNA, their stability to degradation and their pharmacokinetic properties. In a study aimed at investigating new analogues featuring a neutral backbone, we explored the ability of oligomers containing a morpholino-peptide backbone to bind oligonucleotides. Circular Dichroism studies revealed the ability of our oligomers to interact with DNA, molecular modelling studies revealed the interaction responsible for complex stabilization.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Circular dichroism; DNA; Molecular modelling; Morpholino; Peptide
Elenco autori:
A. Contini, E. Erba, V. Bondavalli, A. Barbiroli, M.L. Gelmi, A. Romanelli
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