QT interval variability and QT-HP coupling strength in amyotrophic lateral sclerosis patients
Articolo
Data di Pubblicazione:
2020
Citazione:
QT interval variability and QT-HP coupling strength in amyotrophic lateral sclerosis patients / B. De Maria, G. Mora, K. Marinou, R. Sideri, V. Bari, B. Cairo, E. Vaini, L.A. Dalla Vecchia, A. Porta. - In: COMPUTING IN CARDIOLOGY. - ISSN 2325-887X. - 47(2020). ((Intervento presentato al 47. convegno Computing in Cardiology 2020 tenutosi a Rimini, Italy nel 2020 [10.22489/CinC.2020.268].
Abstract:
n the recentyearswe have witnessed an increasing interest in studying cardiac control in amyotrophic lateral sclerosis (ALS) patients. The variability of the overall duration of cardiac electrical activitycomprising depolarization and repolarization periods,namely the QT interval, could provide information about the cardiac control of ALS patientscomplementary to that derived from the variability of heart period(HP). In this study we evaluate first the HPand QT variabilitiesin 10 ALS patients at rest in supine position (REST) and during 75° head-up tilt (TILT).The QT interval was approximated asRTapex and RTend intervals, representing the temporal distance between R-wave peakand T-wave apex and end, respectively. HP was taken as the time distance between two consecutive R-wave peaks. Time and frequency domain markers were computed overHP, RTa and RTebeat-to-beat series. TheRTa-HPand RTe-HPsquared coherence wascalculated as well. We found that time and frequency domain indexes derived from QT variability changedduring TILT in the direction expected for ahealthy population. Frequency domain HPvariability markers showed a blunted response to TILT.RTa-HPand RTe-HPsquared coherence did not vary during TILT.QT variability and QT-HPcoupling markers in ALS patients showed an apparently normal response to TILT not fully mirrored byHPvariability indexes.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
B. De Maria, G. Mora, K. Marinou, R. Sideri, V. Bari, B. Cairo, E. Vaini, L.A. Dalla Vecchia, A. Porta
Link alla scheda completa: