Structural and Conformational Studies of 3-(6-Chloropyridazin-3-yl)-N,N-dimethylpiperazinium Iodide and 3-(6-Chloropyridazin-3-yl)-N,N-dimethylhomopiperazinium Iodide with Central Nicotinic Action
Articolo
Data di Pubblicazione:
2003
Citazione:
Structural and Conformational Studies of 3-(6-Chloropyridazin-3-yl)-N,N-dimethylpiperazinium Iodide and 3-(6-Chloropyridazin-3-yl)-N,N-dimethylhomopiperazinium Iodide with Central Nicotinic Action / R. Artali, G. Bombieri, F. Meneghetti. - In: HETEROCYCLES. - ISSN 0385-5414. - 60:9(2003), pp. 2085-2094.
Abstract:
The structural characteristics of 3-(6-chloropyridazin-3-yl)-N,N-dimethylpiperazinium iodide (3c) and 3-(6-chloropyridazin-3-yl)-N,N-dimethylhomopiperazinium iodide (4c) have been investigated in order to understand their actions at the nAchR receptor. The results of the X-Ray molecular structures and of the conformational analysis have been compared with the structure of epibatidine that represents one of the most potent nicotinic agonist.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Artali, G. Bombieri, F. Meneghetti
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