Differentiating Hereditary Arrhythmogenic Right Ventricular Cardiomyopathy from Cardiac Sarcoidosis Fulfilling 2010 ARVC Task Force Criteria
Articolo
Data di Pubblicazione:
2021
Citazione:
Differentiating Hereditary Arrhythmogenic Right Ventricular Cardiomyopathy from Cardiac Sarcoidosis Fulfilling 2010 ARVC Task Force Criteria / A. Gasperetti, V. Rossi, A. Chiodini, M. Casella, S. Costa, D. Akdis, R. Büchel, A. Deliniere, E. Pruvot, C. Gruner, C. Carbucicchio, R. Manka, A.D. Russo, C. Tondo, C. Brunckhorst, F. Tanner, F. Duru, A.M. Saguner. - In: HEART RHYTHM. - ISSN 1547-5271. - 18:2(2021), pp. 231-238. [10.1016/j.hrthm.2020.09.015]
Abstract:
Background: Cardiac sarcoidosis (CS) may resemble the clinical presentation of arrhythmogenic right ventricular cardiomyopathy (ARVC).
Objective: goal of our study was identification of clinical variables to better discriminate between patients with genetically-determined ARVC and CS fulfilling definite ARVC 2010 TFC.
Methods: In this multicenter study, 10 patients with CS fulfilling definite 2010 ARVC TFC were age-and gender matched with 10 genetically-proven ARVC patients. A cardiac 18F-FDG PET-scan was required to be included in this study.
Results: The 2010 ARVC TFC did not reliably differentiate between the two diseases. CS patients presented with longer PR-intervals, advanced AVB, and a longer QRS-duration (p <0.001; and p=0.009, respectively), while T wave inversions (TWI) in peripheral leads were more common in ARVC (p=0.009). CS patients presented with more extensive LV involvement and a lower LVEF, while ARVC patients had a larger RVOT (p=0.044). PET scan positivity was only present in CS patients (90% vs 0%).
Conclusion: The 2010 TFC do not reliably differentiate between CS patients fulfilling 2010 TFC and hereditary ARVC. A prolonged PR interval, advanced AVB, longer QRS duration, RV apical involvement, a reduced LVEF, and a positive 18F-FDG PET scan should raise the suspicion of CS, whereas larger RVOT dimensions and peripheral TWI favor the diagnosis of hereditary ARVC.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
arrhyhtmogenic right ventricular cardiomyopathy; cardiac sarcoidosis; cardiomyopathy; genetic; international task force criteria
Elenco autori:
A. Gasperetti, V. Rossi, A. Chiodini, M. Casella, S. Costa, D. Akdis, R. Büchel, A. Deliniere, E. Pruvot, C. Gruner, C. Carbucicchio, R. Manka, A.D. Russo, C. Tondo, C. Brunckhorst, F. Tanner, F. Duru, A.M. Saguner
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