How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study
Articolo
Data di Pubblicazione:
2020
Citazione:
How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study / M. Gacci, W. Artibani, P. Bassi, F. Bertoni, S. Bracarda, A. Briganti, G. Carmignani, L. Carmignani, G. Conti, R. Corvò, C. De Nunzio, F. Fusco, P. Graziotti, I. Greco, S. Maggi, S.M. Magrini, V. Mirone, R. Montironi, G. Morgia, G. Muto, M. Noale, S. Pecoraro, A. Porreca, U. Ricardi, E. Russi, G. Russo, A. Salonia, A. Simonato, S. Serni, D. Tomasini, A. Tubaro, V. Zagonel, G. Crepaldi. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - (2020). [Epub ahead of print] [10.1007/s00345-020-03350-5]
Abstract:
Purpose: Therapeutic strategies for prostate cancer (PCa) have been evolving dramatically worldwide. The current article reports on the evolution of surgical management strategies for PCa in Italy.
Methods: The data from two independent Italian multicenter projects, the MIRROR-SIU/LUNA (started in 2007, holding data of 890 patients) and the Pros-IT-CNR project (started in 2014, with data of 692 patients), were compared. Differences in patients' characteristics were evaluated. Multivariable logistic regression models were used to identify characteristics associated with robot-assisted (RA) procedure, nerve sparing (NS) approach, and lymph node dissection (LND).
Results: The two cohorts did not differ in terms of age and prostate-specific antigen (PSA) levels at biopsy. Patients enrolled in the Pros-IT-CNR project more frequently were submitted to RA (58.8% vs 27.6%, p < 0.001) and NS prostatectomy (58.4% vs. 52.9%, p = 0.04), but received LND less frequently (47.7% vs. 76.7%, p < 0.001), as compared to the MIRROR-SIU/LUNA patients. At multivariate logistic models, Lower Gleason Scores (GS) and PSA levels were significantly associated with RA prostatectomy in both cohorts. As for the MIRROR-SIU/LUNA data, clinical T-stage was a predictor for NS (OR = 0.07 for T3, T4) and LND (OR = 2.41 for T2) procedures. As for Pros-IT CNR data, GS ≥ (4 + 3) and positive cancer cores ≥ 50% were decisive factors both for NS (OR 0.29 and 0.30) and LND (OR 7.53 and 2.31) strategies.
Conclusions: PCa management has changed over the last decade in Italian centers: RA and NS procedures without LND have become the methods of choice to treat newly medium-high risk diagnosed PCa.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Lymph node dissection; MIRROR SIU/LUNA study; Nerve sparing; Pros-IT CNR study; Prostate cancer; Robotic procedures
Elenco autori:
M. Gacci, W. Artibani, P. Bassi, F. Bertoni, S. Bracarda, A. Briganti, G. Carmignani, L. Carmignani, G. Conti, R. Corvò, C. De Nunzio, F. Fusco, P. Graziotti, I. Greco, S. Maggi, S.M. Magrini, V. Mirone, R. Montironi, G. Morgia, G. Muto, M. Noale, S. Pecoraro, A. Porreca, U. Ricardi, E. Russi, G. Russo, A. Salonia, A. Simonato, S. Serni, D. Tomasini, A. Tubaro, V. Zagonel, G. Crepaldi
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