Mediterranean diet, Dietary Approaches to Stop Hypertension, and Pro-vegetarian dietary pattern in relation to the risk of basal cell carcinoma: a nested case-control study within the Seguimiento Universidad de Navarra (SUN) cohort
Articolo
Data di Pubblicazione:
2020
Citazione:
Mediterranean diet, Dietary Approaches to Stop Hypertension, and Pro-vegetarian dietary pattern in relation to the risk of basal cell carcinoma: a nested case-control study within the Seguimiento Universidad de Navarra (SUN) cohort / A. Leone, M.Á. Martínez-González, A. Martin-Gorgojo, R. Sánchez-Bayona, R. De Amicis, S. Bertoli, A. Battezzati, M. Bes-Rastrollo. - In: THE AMERICAN JOURNAL OF CLINICAL NUTRITION. - ISSN 0002-9165. - 112:2(2020 Aug), pp. 364-372. [10.1093/ajcn/nqaa127]
Abstract:
Background
The association of dietary pattern with the risk of basal cell carcinoma (BCC) is little understood and has scarcely been investigated.
Objectives
We assessed the association of several complete dietary patterns [Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Pro-vegetarian dietary pattern] with the risk of BCC, conducting a nested case-control study (4 controls for each case).
Methods
Cases and controls were selected from the SUN (Seguimiento Universidad de Navarra) cohort using risk set sampling. Cases were identified among subjects free of skin cancer at baseline but who later reported a physician-made BCC diagnosis during the follow-up period. In the cohort we identified 101 incident cases of BCC.
Results
In multivariable-adjusted conditional logistic regression analyses, better adherence to the Mediterranean diet (highest compared with lowest quintile) was associated with a 72% relative reduction in the odds of BCC (OR: 0.28; 95% CI: 0.10, 0.77; Ptrend = 0.014); the DASH diet was associated with a 68% RR reduction (OR: 0.32; 95% CI: 0.14, 0.76; Ptrend = 0.013) for the comparison between extreme quintiles. No association was found between a Pro-vegetarian dietary pattern and BCC. Higher fruit consumption (highest compared with lowest quintile, OR: 0.27; 95% CI: 0.11, 0.64; Ptrend < 0.001) and low-fat dairy products (OR: 0.39; 95% CI: 0.16, 0.92; Ptrend = 0.014) were associated with a lower BCC risk.
Conclusions
Our results suggest that Mediterranean and DASH dietary patterns may be associated with a lower risk of BCC, but confirmatory studies are required.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
DASH diet; Mediterranean diet; Pro-vegetarian diet; basal cell carcinoma; dietary pattern; skin cancer
Elenco autori:
A. Leone, M.Á. Martínez-González, A. Martin-Gorgojo, R. Sánchez-Bayona, R. De Amicis, S. Bertoli, A. Battezzati, M. Bes-Rastrollo
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