Effetto anticonvulsivante della neurotossina botulinica di tipo E (BoNT/E) = effects of botulinum neurotoxin type E (BoNT/E)
Articolo
Data di Pubblicazione:
2006
Citazione:
Effetto anticonvulsivante della neurotossina botulinica di tipo E (BoNT/E) = effects of botulinum neurotoxin type E (BoNT/E) / F. Antonucci, Y. Bozzi, E. Novelli, F. Sartucci, M. Caleo. - In: BOLLETTINO-LEGA ITALIANA CONTRO L'EPILESSIA. - ISSN 0394-560X. - 133-134(2006), pp. 55-57.
Abstract:
Temporal Lobe Epilepsy (TLE) is one of the most common forms of human epilepsy and is burdened by a high rate of refractoriness to medical therapy. One therapeutic option currently under investigation in experimental models, is the delivery of anticonvulsant agents with long-lasting action directly into the seizure focus in the brain. Botulinum neurotoxin E (BoNT/E) is a bacterial protease that exert a prolonged blockade of synaptic activity by cleaving the synaptosomal-associated protein of 25 KDa (SNAP-25). Here we demonstrate by extracellular recordings and immunodetection of BoNT/E-cleaved SNAP-25 that BoNT/E effects persist for at least 14 days in the injected hippocampus. We also investigate the anticonvulsant properties of intrahippocampal injections of BoNT/E in a mouse model of TLE, in which limbic recurrent seizures follow kainic acid-induced status epilepticus. Preliminary data indicate that BoNT/E delivery is anticonvulsant on chronic paroxysmal discharges in this model of TLE.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Neurotransmitter release; Kainic acid; Anticonvulsant effects; Spikes
Elenco autori:
F. Antonucci, Y. Bozzi, E. Novelli, F. Sartucci, M. Caleo
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