Poly(amidoamine)s with 2-Dithiopyridine Side Substituents as Intermediates to Peptide-polymer Conjugates
Articolo
Data di Pubblicazione:
2007
Citazione:
Poly(amidoamine)s with 2-Dithiopyridine Side Substituents as Intermediates to Peptide-polymer Conjugates / E. Ranucci, M. A. Suardi, P. Ferruti, A. Manfredi. - In: MACROMOLECULAR RAPID COMMUNICATIONS. - ISSN 1022-1336. - 28:11(2007), pp. 1243-1250.
Abstract:
Cystamine, when employed as a cross-linking agent, leads to poly(amidoamine) networks, which on reaction with 2,2-dithiodipyridine turn into linear poly(amidoamine)s with side dithiopyridyl groups that easily undergo exchange reactions with reduced L-glutathione, a model thiol-containing biologically active peptide. The resultant products represent the first examples of soluble poly(amidoamine)-peptide conjugates in which the peptide moieties are linked to the polymer chain by SS bonds stable in blood, but cleavable inside cells.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
biocompatibility ; biodegradable ; disulfide-containing polymers ; functionalization of polymers ; poly(amidoamine)s ; polymer-peptide conjugates
Elenco autori:
E. Ranucci, M. A. Suardi, P. Ferruti, A. Manfredi
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