Spinal direct current stimulation (tsDCS) in hereditary spastic paraplegias (HSP): A sham-controlled crossover study
Articolo
Data di Pubblicazione:
2021
Citazione:
Spinal direct current stimulation (tsDCS) in hereditary spastic paraplegias (HSP): A sham-controlled crossover study / G. Ardolino, T. Bocci, M. Nigro, M. Vergari, A. Di Fonzo, S. Bonato, F. Cogiamanian, F. Cortese, I. Cova, S. Barbieri, A. Priori. - In: THE JOURNAL OF SPINAL CORD MEDICINE. - ISSN 1079-0268. - 44:1(2021 Jan 02), pp. 46-53. [10.1080/10790268.2018.1543926]
Abstract:
Objective: Hereditary spastic paraplegia (HSP) represents a heterogeneous group of neurodegenerative
diseases characterized by progressive spasticity and lower limb weakness. We assessed the effects of
transcutaneous spinal direct current stimulation (tsDCS) in HSP.
Design: A double-blind, randomized, crossover and sham-controlled study.
Setting: Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan.
Participants: eleven patients with HSP (six men, mean age ± SD: 37.3 ± 8.1 years), eight affected by spastin/
SPG4,1 by atlastin1/SPG3a, 1 by paraplegin/SPG7 and 1 by ZFYVE26/SPG15.
Interventions: tsDCS (anodal or sham, 2.0 mA, 20’, five days) delivered over the thoracic spinal cord (T10-T12).
Outcome measures: Motor-evoked potentials (MEPs), the H-reflex (Hr), F-waves, the Ashworth scale for clinical
spasticity, the Five Minutes Walking test and the Spastic Paraplegia Rating Scale (SPRS) were assessed.
Patients were evaluated before tsDCS (T0), at the end of the stimulation (T1), after one week (T2), one month
(T3) and two months (T4).
Results: The score of the Ashworth scale improved in the anodal compared with sham group, up to two months
following the end of stimulation (T1, P = .0137; T4, P = .0244), whereas the Five Minutes Walking test and SPRS
did not differ between the two groups. Among neurophysiological measures, both anodal and sham tsDCS left
Hr, F-waves and MEPs unchanged over time.
Conclusions: Anodal tsDCS significantly decreases spasticity and might be a complementary strategy for the
treatment of spasticity in HSP.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Hereditary spastic paraplegias; Movement disorders; Non-invasive spinal stimulation; Spasticity treatment; Transcutaneous spinal direct current stimulation
Elenco autori:
G. Ardolino, T. Bocci, M. Nigro, M. Vergari, A. Di Fonzo, S. Bonato, F. Cogiamanian, F. Cortese, I. Cova, S. Barbieri, A. Priori
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