Data di Pubblicazione:
2018
Citazione:
Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs / E. Ranucci, A. Manfredi, P. Ferruti, E. Martí Coma-Cros, A. Biosca, J. Marques, L. Carol, P. Urbán, D. Berenguer, C. Riera Maria, M. Delves, E. Sinden Robert, O. Valle-Delgado Juan, L. Spanos, I. Siden-Kiamosn, P. Pérez, K. Paaijmans, M. Rottmann, X. Fernàndez-Busquets. - In: PHARMACEUTICS. - ISSN 1999-4923. - 10:4(2018 Nov 11), pp. 225.1-225.20. [10.3390/pharmaceutics10040225]
Abstract:
Current strategies for the mass administration of antimalarial drugs demand oral
formulations to target the asexual Plasmodium stages in the peripheral bloodstream, whereas
recommendations for future interventions stress the importance of also targeting the transmission
stages of the parasite as it passes between humans and mosquitoes. Orally administered
polyamidoamine (PAA) nanoparticles conjugated to chloroquine reached the blood circulation and
cured Plasmodium yoelii-infected mice, slightly improving the activity of the free drug and inducing
in the animals immunity against malaria. Liquid chromatography with tandem mass spectrometry
analysis of affinity chromatography-purified PAA ligands suggested a high adhesiveness of PAAs
to Plasmodium falciparum proteins, which might be the mechanism responsible for the preferential
binding of PAAs to Plasmodium-infected erythrocytes vs. non-infected red blood cells. The weak
antimalarial activity of some PAAs was found to operate through inhibition of parasite invasion,
whereas the observed polymer intake by macrophages indicated a potential of PAAs for the treatment
of certain coinfections such as Plasmodium and Leishmania. When fluorescein-labeled PAAs were fed
to females of the malaria mosquito vectors Anopheles atroparvus and Anopheles gambiae, persistent
fluorescence was observed in the midgut and in other insect’s tissues. These results present PAAs as
a versatile platform for the encapsulation of orally administered antimalarial drugs and for direct
administration of antimalarials to mosquitoes, targeting mosquito stages of Plasmodium.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Anopheles; antimalarial drugs; malaria; mosquitoes; nanomedicine; nanotechnology; Plasmodium; polymers; polyamidoamines; targeted drug delivery
Elenco autori:
E. Ranucci, A. Manfredi, P. Ferruti, E. Martí Coma-Cros, A. Biosca, J. Marques, L. Carol, P. Urbán, D. Berenguer, C. Riera Maria, M. Delves, E. Sinden Robert, O. Valle-Delgado Juan, L. Spanos, I. Siden-Kiamosn, P. Pérez, K. Paaijmans, M. Rottmann, X. Fernàndez-Busquets
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