Data di Pubblicazione:
2019
Citazione:
Lipids and Mass Spectrometry Application / R. Spezzano ; tutor: D. Caruso ; coordinator: A. Prinetti. DIPARTIMENTO DI SCIENZE FARMACOLOGICHE E BIOMOLECOLARI, 2019 May 30. 31. ciclo, Anno Accademico 2018. [10.13130/spezzano-roberto_phd2019-05-30].
Abstract:
During my PhD courses I focused attention on the applications of mass spectrometry in lipidomic studies. I applied mass spectrometry in several experimental models to try to observe differences in selected metabolites affected by a particular pathology.
The first project performed in experimental model of impaird lipogenesis highlighted a cross talk between altered fatty acid synthesis and neuroactive steroid levels.
The second project, mass spectrometry application allows to understand he effect of short-term diabetes on cholesterol metabolism.
In the last project lipidomic pattern was investigated in experimental model of SCA38. Results obtained highlighted as elovl5 mutation affect phospholipids profile.
Tipologia IRIS:
Tesi di dottorato
Keywords:
Lipidomic; Mass spectrometry
Elenco autori:
R. Spezzano
Link alla scheda completa: