Data di Pubblicazione:
2018
Citazione:
A concise, practical synthesis of 2,3-dihydro-1,5-benzothiazepines / D.C.M. Albanese. ((Intervento presentato al convegno Euro Chemistry Conference tenutosi a Roma nel 2018.
Abstract:
We have developed a domino process involving the Michael addition of 2-aminothiophenols to chalcones, followed by in situ cyclization. Up to 98% chemical yields have been obtained at room temperature by using hexafluoro-2-propanol (HFIP). The reaction was found to be tolerant to a number of electron-withdrawing or electron-releasing substituents on chalcones.
In order to access the feasibility of the procedure on larger scale a few experiments have been carried out by recovering and recycling HFIP in subsequent runs. The yield of 2,3-dihydro-1,5-benzothiazepine remained unchanged and only minor amounts of HFIP was added in order to restore identical initial conditions.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Keywords:
1,5-benzothiazepines; green chemistry; hexafluoro-2-propanol; Michael addition; domino process
Elenco autori:
D.C.M. Albanese
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