Multiplex array analysis of circulating cytokines and chemokines in natalizumab-treated patients with multiple sclerosis
Articolo
Data di Pubblicazione:
2017
Citazione:
Multiplex array analysis of circulating cytokines and chemokines in natalizumab-treated patients with multiple sclerosis / S. Villani, N. Zanotta, F. Ambrogi, M. Comar, D. Franciotta, M. Dolci, C. Cason, R. Ticozzi, P. Ferrante, S. Delbue. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 310(2017 Sep 15), pp. 91-96.
Abstract:
Natalizumab greatly reduces inflammatory relapses in multiple sclerosis (MS) by blocking the integrin-mediated leukocyte traffic to the brain, but less is known about its effects on the systemic immunity. We measured 48 cytokines/chemokines in sera from 19 natalizumab-treated MS patients. Serum concentrations of both anti-(IL-10, IL1ra) and pro-inflammatory (IL7, IL16) molecules decreased after 21-month treatment, without associations to unbalanced Th2/Th1cytokine ratios, clinical responses, and blood/urine replication of polyomavirus JC (JCPyV). No patient developed the JCPyV-related progressive multifocal leukoencephalopathy (PML), the major risk factor of natalizumab therapy. Our data suggest that natalizumab has marginal impact on the systemic immunity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cytokines; JC virus; Natalizumab; Adult; Antibodies, Viral; Cytokines; Female; Follow-Up Studies; Humans; Immunologic Factors; Intercellular Signaling Peptides and Proteins; JC Virus; Male; Multiple Sclerosis; Natalizumab; T-Lymphocyte Subsets; Time Factors; Immunology and Allergy; Immunology; Neurology; Neurology (clinical)
Elenco autori:
S. Villani, N. Zanotta, F. Ambrogi, M. Comar, D. Franciotta, M. Dolci, C. Cason, R. Ticozzi, P. Ferrante, S. Delbue
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