Role of tissue C-reactive protein in atrial cardiomyocytes of patients undergoing catheter ablation of atrial fibrillation: Pathogenetic implications
Articolo
Data di Pubblicazione:
2011
Citazione:
Role of tissue C-reactive protein in atrial cardiomyocytes of patients undergoing catheter ablation of atrial fibrillation: Pathogenetic implications / M.L. Narducci, G. Pelargonio, A. Dello Russo, M. Casella, L.M. Biasucci, G. LA TORRE, V. Pazzano, P. Santangeli, A. Baldi, G. Liuzzo, C. Tondo, A..P.L. Natale, F. Crea. - In: EUROPACE. - ISSN 1099-5129. - 13:8(2011), pp. 1133-1140.
Abstract:
Aims: Histological studies support the important role of inflammation in the initiation and maintenance of atrial fibrillation (AF). We describe a novel and safe technique of atrial biopsy during AF radiofrequency catheter ablation (RFCA) to investigate the role of atrial tissue inflammation. Methods and results: We enrolled 70 consecutive patients (age 60 ± 12 years, 49 males) undergoing RFCA for AF. The control group was represented by 10 patients with WolffParkinsonWhite syndrome undergoing trans-septal puncture. Atrial biopsies were obtained by washing the dilator and needle used for trans-septal puncture with 20 mL sterile phosphate-buffered saline. The presence of intracytoplasmic C-reactive protein was assessed in formalin-fixed atrial specimens by immunohistochemistry. A sufficient amount of atrial tissue was obtained in 23/70 (32) patients with AF and in 4/10 (40) of the control group. Intracytoplasmic localization of C-reactive protein was found in isolated atrial cardiomyocytes in 11 (73) of 15 patients with paroxysmal AF as compared with 2 (25) of eight patients with persistent AF (P 0.02). Conclusions: In this study, we demonstrate the safety and feasibility of a novel technique to obtain atrial specimens during routine trans-septal puncture. Local inflammation assessed by atrial tissue localization of C-reactive protein is more likely involved in paroxysmal rather than in persistent AF.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Atrial endomyocardial biopsy; Atrial fibrillation; C-reactive protein; Trans-septal puncture; Aged; Biomarkers; Biopsy; C-Reactive Protein; Cytoplasm; Feasibility Studies; Female; Follow-Up Studies; Heart Atria; Humans; Male; Middle Aged; Myocarditis; Myocytes, Cardiac; Prospective Studies; Wolff-Parkinson-White Syndrome; Atrial Fibrillation; Catheter Ablation; Cardiology and Cardiovascular Medicine; Physiology (medical)
Elenco autori:
M.L. Narducci, G. Pelargonio, A. Dello Russo, M. Casella, L.M. Biasucci, G. LA TORRE, V. Pazzano, P. Santangeli, A. Baldi, G. Liuzzo, C. Tondo, A..P.L. Natale, F. Crea
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