Biomarkers of myocardial injury with different energy sources for atrial fibrillation catheter ablation
Articolo
Data di Pubblicazione:
2014
Citazione:
Biomarkers of myocardial injury with different energy sources for atrial fibrillation catheter ablation / M. Casella, A.D. Russo, E. Russo, G. Al-Mohani, P. Santangeli, S. Riva, G. Fassini, M. Moltrasio, E. Innocenti, D. Colombo, F. Bologna, G. Izzo, G. Joseph, L.D. Biase, A. Natale, C. Tondo. - In: CARDIOLOGY JOURNAL. - ISSN 1897-5593. - 21:5(2014), pp. 516-523. [10.5603/CJ.a2013.0153]
Abstract:
Background: Our study aims to compare acute myocardial injury biomarker rise after atrial fibrillation ablation performed with different technologies.Methods and Results: One hundred and ten patients were treated with pulmonary vein isolation with 4 different technologies: open-irrigated tip radiofrequency (RF) catheter in 35 patients (Group A), cryoballoon in 35 patients (Group B), visually guided laser balloon in 20 patients (Group C), open-irrigated tip RF catheter with contact-force-sensing technology in 20 patients (Group D). Post-procedure samples of cardiac troponin I (cTnI) and creatinine kinase-MB (CK-MB) were collected at 19 ± 3 h and 43 ± 3 h after ablation. At the first postprocedural sample, cTnI and CK-MB levels were found elevated in all 110 patients with a median value of 2.11 ng/mL and 8.95 ng/mL, respectively. Group B showed cTnI levels increased (median 5.96 ng/mL) compared to other groups (median Group A: 1.72 ng/mL, Group C: 1.54 ng/mL, Group D: 2.0 ng/mL; p < 0.001). Also CK-MB levels resulted higher in cryoablation (median 26.4 ng/mL) compared to other groups (median Group A: 6.40 ng/mL, Group C: 7.15 ng/mL, Group D: 6.50 ng/mL; p < 0.001). No significant association was observed between biomarker levels and recurrences of atrial fibrillation after a mean follow-up of 369 ± 196 days.Conclusions: Highest markers for myocardial injury were observed in the cryoballoon group. It is possible that a longer delivery energy duration and other factors affecting lesion size resulted in higher amount of cardiac injury in cryoablation. The higher levels of cardiac biomarkers did not translate into a better outcome and its physiologic significance is unknown.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Atrial fibrillation ablation; Cardiac biochemical markers; Cardiac troponin I; Creatinine kinase-MB; Myocardial injury; Atrial Fibrillation; Biomarkers; Catheter Ablation; Creatine Kinase, MB Form; Cryosurgery; Echocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Postoperative Complications; Prospective Studies; Pulmonary Veins; Severity of Illness Index; Troponin I; Troponin T; Cardiology and Cardiovascular Medicine
Elenco autori:
C. Michela, R. Antonio Dello, R. Eleonora, A. Ghaliah, S. Pasquale, R. Stefania, F. Gaetano, M. Massimo, E. Innocenti, D. Colombo, B. Fabrizio, I. Gennaro, J. G., B. Luigi Di, A. Natale, C. Tondo
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