Effect of Aerobic Physical Activity on Inflammatory and Autoimmune Parameters in Type 1 Diabetes
Abstract
Data di Pubblicazione:
2016
Citazione:
Effect of Aerobic Physical Activity on Inflammatory and Autoimmune Parameters in Type 1 Diabetes / R. Codella, F. Casiraghi, M. Adamo, A. Ferrulli, C. Macrì, E. Bazzigaluppi, I. Terruzzi, L. Inverardi, C. Ricordi, L. Luzi. - In: DIABETES. - ISSN 0012-1797. - 65:(2016 Jun 01), pp. A192-A192. ((Intervento presentato al 76. convegno Scientific Sessions of the American-Diabetes-Association (ADA) tenutosi a New Orleans (LA, USA) nel 2016.
Abstract:
In a retrospective analysis of a type 1 diabetic (T1D) population, a subset
of patients performing higher aerobic activity showed a reduced title of anti-
GAD and anti-IA2 compared to sedentary T1D (Eur Rev Pharmacol Sci, 2015).
For this reason we hypothesized that aerobic physical activity may positively
regulate autoimmunity in diabetes. We tested this hypothesis in nonobese
diabetic mice in a longitudinal study, confi rming the benefi cial immunomodulatory
potential of aerobic physical activity (J Diabetes Res, 2015). This study
focuses on the effects of a 3-month aerobic physical activity on metabolic,
infl ammatory and autoimmune parameters in T1D patients on insulin pump
therapy. Thirteen T1D patients, 4 sedentary (2M, 2F; 40.5±5.2 years; BMI
27.7±3.8) and 9 physically active (8M, 1F; 36.5±8.8 years; BMI 24.1±1.9),
monitored with an insulin pump, were studied. At baseline and at the end
of a 3-month aerobic physical activity, several blood parameters and markers,
such as glycosylated hemoglobin (Hb1Ac), auto-antibodies (anti-GAD,
anti-ZnT8, anti-IA2, ICA) and proinfl ammatory cytokines (IL-6 and TNF-α),
were evaluated. After 3 months of training, physically active T1D patients,
compared with the sedentary ones, showed a signifi cant reduction in Hb1Ac
(-8.7%, p<0.01). Also, their Hb1Ac signifi cantly decreased compared to themselves
at baseline (-10%, p<0.03). At the end of the study, anti-GAD titles
were found signifi cantly lower in the active subjects compared with the sedentary
ones (-74%, p<0.04). No signifi cant differences were observed as to
the other autoantibodies and infl ammatory cytokines. This study confi rms
the benefi cial role of physical exercise associated with insulin pump therapy
in order to improve metabolic control without signifi cantly increasing hypoglycemic
episodes. Preliminary positive results on autoimmune parameters
need to be confi rmed in a prolonged follow-up.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Codella, F. Casiraghi, M. Adamo, A. Ferrulli, C. Macrì, E. Bazzigaluppi, I. Terruzzi, L. Inverardi, C. Ricordi, L. Luzi
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