Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy
Articolo
Data di Pubblicazione:
2009
Citazione:
Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy / F. Antonucci, Y. Bozzi, M. Caleo. - In: EPILEPSIA. - ISSN 1528-1167. - 50:4(2009 Apr), pp. 963-966.
Abstract:
Mesial temporal lobe epilepsy (MTLE) is one of the most common forms of human epilepsy, and it is often resistant to conventional antiepileptic drug (AED) therapy. Here we tested whether a single intrahippocampal administration of the synaptic blocker botulinum neurotoxin E (BoNT/E) is effective in reducing spontaneous recurrent seizures (SRS) in a mouse model of MTLE. Unilateral intrahippocampal injection of kainic acid (KA) in mice was used as a model of MTLE. Electroencephalography (EEG) recordings of SRS were performed during the chronic phase of epilepsy, before and after administration of either BoNT/E or vehicle. Frequency of SRS was significantly decreased for at least 5 days following BoNT/E, but not vehicle, infusion. Our findings demonstrate that BoNT/E can effectively reduce seizure incidence in a mouse model of MTLE.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
mesial temporal lobe epilepsy; spontaneous recurrent seizures; Kainic acid; SNAP-25; granule cell dispersion
Elenco autori:
F. Antonucci, Y. Bozzi, M. Caleo
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