Data di Pubblicazione:
2016
Citazione:
From anilines to aziridines : A two-step synthesis under continuous-flow conditions / S. Rossi, A. Puglisi, D. Intrieri, E. Gallo. - In: JOURNAL OF FLOW CHEMISTRY. - ISSN 2062-249X. - 6:3(2016 Sep), pp. 234-239. [10.1556/1846.2016.00027]
Abstract:
The Sandmeyer reaction of anilines to generate aryl azides, followed by the Ru(porphyrin)CO-catalyzed addition to styrenes affording N-aryl aziridines was successfully performed for the first time in mesoreactors, under continuous-flow conditions. Mesofluidic technology allowed for a rapid screening of different parameters and a quick identification of the optimized reaction conditions for the two separate steps. The two optimized reactions were then combined in a single continuous process that allowed a safe and efficient synthesis of N-arylaziridines from convenient commercially available starting materials.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
azides; aziridines; flow chemistry; mesoreactors; ruthenium catalyst; chemistry (miscellaneous); fluid flow and transfer processes; organic chemistry
Elenco autori:
S. Rossi, A. Puglisi, D. Intrieri, E. Gallo
Link alla scheda completa: