Coxsackievirus adenovirus receptor loss impairs adult neurogenesis, synapse content, and hippocampus plasticity
Articolo
Data di Pubblicazione:
2016
Citazione:
Coxsackievirus adenovirus receptor loss impairs adult neurogenesis, synapse content, and hippocampus plasticity / C. Zussy, F. Loustalot, F. Junyent, F. Gardoni, C. Bories, J. Valero, M.G. Desarménien, F. Bernex, D. Henaff, N. Bayo Puxan, J. Chen, N. Lonjon, Y. de Koninck, J.O. Malva, J.M. Bergelson, M.M.G. Di Luca, G. Schiavo, S. Salinas, E.J. Kremer. - In: THE JOURNAL OF NEUROSCIENCE. - ISSN 0270-6474. - 36:37(2016 Sep), pp. 9558-9571. [10.1523/JNEUROSCI.0132-16.2016]
Abstract:
Although we are beginning to understand the latest age of neurodegenerative diseases, the molecular defects associated with the initiation of impaired cognition are poorly characterized. Here, we demonstrate that in the adult brain, the coxsackievirus and adenovirus receptor (CAR) is located on neuron projections, at the presynapse in mature neurons, and on the soma of immature neurons in the hippocampus. In a proinflammatory or diseased environment, CAR is lost from immature neurons in the hippocampus. Strikingly, in hippocampi of patients at early stages of late-onset Alzheimer’s disease (AD), CAR levels are significantly reduced. Similarly, in triple-transgenic AD mice, CAR levels in hippocampi are low and further reduced after systemic inflammation. Genetic deletion of CAR from the mouse brain triggers deficits in adult neurogenesis and synapse homeostasis that lead to impaired hippocampal plasticity and cognitive deficits. We propose that post-translational CAR loss of function contributes to cognitive defects in healthy and diseased-primed brains.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
adult neurogenesis; Alzheimer’s disease; Coxsakievirus and adenovirus receptor; Inflammation; synapse; neuroscience (all)
Elenco autori:
C. Zussy, F. Loustalot, F. Junyent, F. Gardoni, C. Bories, J. Valero, M.G. Desarménien, F. Bernex, D. Henaff, N. Bayo Puxan, J. Chen, N. Lonjon, Y. de Koninck, J.O. Malva, J.M. Bergelson, M.M.G. Di Luca, G. Schiavo, S. Salinas, E.J. Kremer
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