Data di Pubblicazione:
2010
Citazione:
Covalent modifications of albumin Cys34 as a biomarker of mild oxidative dtress / G. Aldini, K. Yeum, G. Vistoli - In: Biomarkers for antioxidant defense and oxidative damage: principles and practical applications / [a cura di] G. Aldini, K.-J. Yeum, E. Niki, R.M. Russell. - [s.l] : Wiley-Blackwell, 2010. - ISBN 9780813815350. - pp. 229-241 [10.1002/9780813814438.ch14]
Tipologia IRIS:
03 - Contributo in volume
Keywords:
Albumin Cys34 and its oxidized forms -potential biomarkers of oxidative damage; Covalent modifications of albumin Cys34 -as mild oxidative stress biomarker; CYS34 acting -as an antioxidant; Cys34, reactive antioxidant and detoxifying residues -of electrophilic species; Direct infusion MS, infusing solutions of isolated albumin dissolved in denaturing solvent; Human serum albumin (HSA), abundant protein in plasma -60% of total circulating proteins; LC-ESI-MS approach for identification -of unknown and predicted modifications of Cys34; Mercaptoalbumin, markers of antioxidant status; Molecular mechanisms of mercaptoalbumin -as extracellular antioxidant, main oxidation products; Serum albumin concentration and mortality risk-inverse relationship
Elenco autori:
G. Aldini, K. Yeum, G. Vistoli
Link alla scheda completa:
Titolo del libro:
Biomarkers for antioxidant defense and oxidative damage: principles and practical applications