Interleukin-8 and CXCR1 Receptor Functional Polymorphisms and Susceptibility to Acute Pyelonephritis
Articolo
Data di Pubblicazione:
2007
Citazione:
Interleukin-8 and CXCR1 Receptor Functional Polymorphisms and Susceptibility to Acute Pyelonephritis / L. Artifoni, S. Negrisolo, G. Montini, P. Zucchetta, P.P. Molinari, W. Cassar, R. Destro, F. Anglani, W. Rigamonti, G. Zacchello, L. Murer. - In: THE JOURNAL OF UROLOGY. - ISSN 0022-5347. - 177:3(2007 Mar), pp. 1102-1106.
Abstract:
Purpose: We performed a case-control study in children diagnosed by the first episode of upper urinary tract infection with or without vesicoureteral reflux to evaluate the association of functional polymorphism of interleukin-8 (-251A>T and +2767A>G), and its receptor CXCR1 (+2607G>C). Materials and Methods: Genomic DNA was obtained from 265 children with a clinical and laboratory diagnosis of urinary tract infection who were recruited in northeast Italy. The children were subdivided as 173 who were dimercapto-succinic acid scan positive with positive static renal scintigraphy in acute conditions, consistent with the diagnosis of acute pyelonephritis, and 92 who were dimercapto-succinic acid scan negative. Genetic analysis for the same polymorphisms was also extended to a control population of 106 umbilical cord DNA samples. Results: Statistical analysis of genotype data showed that 1) the tested populations were in Hardy-Weinberg equilibrium, 2) there were significant differences between the dimercapto-succinic acid scan positive and negative groups (p = 0.049), and the dimercapto-succinic acid scan positive group vs controls (p = 0.032) in terms of interleukin-8 -251A>T polymorphism frequency, 3) there was also a significant difference in the distribution of IL-8 -251A>T and +2767A>G polymorphisms between dimercapto-succinic acid scan positive and negative children in the subgroup without vesicoureteral reflux (p = 0.03 and 0.02, respectively) and 4) no significant differences were found in the frequency of the distribution of CXCR1 +2607G>C polymorphism in all groups. Conclusions: These data suggest that the gene for the proinflammatory chemokine interleukin-8 is involved in susceptibility to acute pyelonephritis during upper urinary tract infection in children with or without vesicoureteral reflux.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
chemokines; genetic; polymorphism; pyelonephritis; urinary tract; urinary tract infections; Acute Disease; Case-Control Studies; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Humans; Infant; Infant, Newborn; Interleukin-8; Male; Polymorphism, Genetic; Pyelonephritis; Receptors, Interleukin-8A; Urinary Tract Infections; Vesico-Ureteral Reflux; Urology
Elenco autori:
L. Artifoni, S. Negrisolo, G. Montini, P. Zucchetta, P.P. Molinari, W. Cassar, R. Destro, F. Anglani, W. Rigamonti, G. Zacchello, L. Murer
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