Asenapine in the Treatment od Acute Mania : a Real-World Observational Study with 6 Months Follow-up
Articolo
Data di Pubblicazione:
2015
Citazione:
Asenapine in the Treatment od Acute Mania : a Real-World Observational Study with 6 Months Follow-up / E.G. Ostinelli, S. Cavallotti, A. Castelnovo, E. Guanella, O. Gambini, A. D'Agostino. - In: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. - ISSN 0271-0749. - 35:5(2015 Oct), pp. 553-558. [10.1097/JCP.0000000000000374]
Abstract:
Asenapine is a second-generation antipsychotic with a unique
pharmacological profile that was recently approved for the treatment of
moderate/severe manic episodes. Real-world data on rapidity of action in
inpatient settings are lacking.
The aims of the current real-world observational study were to evaluate:
(i) short-term efficacy of asenapine after 7 days (T0-T1) in patients
hospitalized for a manic episode in the course of bipolar I disorder or
schizoaffective disorder (group A), (ii) differences in length of stay (LoS),
and (iii) rehospitalization compared to a control population (group B) with
a 6-month follow-up.
Twenty patients were included in each group. The mean total Young
Mania Rating Scale score decreased by 12.6 (SD ±10.3; t(17) = 5.2,
P < 0.005), implying a mean 37.8% improvement. A statistically significant
reduction was observed for all Young Mania Rating Scale items, except for
“sexual interest.” The mean total BPRS score decreased by 17.2 (SD
±14.9; t(17) = 4.9, P < 0.005). A statistically significant reduction was observed
for several items, including “conceptual disorganization,” “grandiosity,”
“unusual thought content,” and “excitement”. Length of stay was 17.9
(SD ±9.0) days for group A and 14.7 (SD ±12.7) days for group B; the result
of the Kruskal-Wallis test showed no significant differences (χ2 = 2.199, P =
0.138). Despite a high discontinuation rate, only 17.7% of patients in group
Awere rehospitalized in the following 6 months compared to 41.2% of those
in group B (relative risk = 0.43, 95% confidence interval, 0.13–1.39).
Findings from this small, preliminary study at least partially support
the results of previous trials, confirming effectiveness and tolerability in the
context of comorbidity and polypsychopharmacology.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
mood disorder; affective psychosis; manic episode; second-generation antipsychotics
Elenco autori:
E.G. Ostinelli, S. Cavallotti, A. Castelnovo, E. Guanella, O. Gambini, A. D'Agostino
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