Data di Pubblicazione:
2016
Citazione:
Nutritional therapy for non-alcoholic fatty liver disease / P. Dongiovanni, C. Lanti, P. Riso, L. Valenti. - In: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. - ISSN 0955-2863. - 29(2016 Mar 01), pp. 1-11. [10.1016/j.jnutbio.2015.08.024]
Abstract:
Following the epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) has become the leading cause of liver disease in western countries. NAFLD is the hepatic manifestation of metabolic syndrome and may progress to cirrhosis and hepatocellular carcinoma. To date, there are no approved drugs for the treatment of NAFLD, and the main clinical recommendation is lifestyle modification, including increase of physical activity and the adoption of a healthy eating behavior. In this regard, studies aimed to elucidate the effect of dietary interventions and the mechanisms of action of specific food bioactives are urgently needed.
The present review tries to summarize the most recent data evidencing the effects of nutrients and dietary bioactive compounds intake (i.e., long-chain PUFA, Vitamin E, Vitamin D, minerals and polyphenols) on the modulation of molecular mechanisms leading to fat accumulation, oxidative stress, inflammation and liver fibrosis in NAFLD patients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Nonalcoholic fatty liver disease (NAFLD; food bioactives; molecular mechanisms; in vitro studies; animal models; clinical trials
Elenco autori:
P. Dongiovanni, C. Lanti, P. Riso, L. Valenti
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