Renal involvement in hypocomplementaemic urticarial vasculitis syndrome : a report of three paediatric cases
Articolo
Data di Pubblicazione:
2014
Citazione:
Renal involvement in hypocomplementaemic urticarial vasculitis syndrome : a report of three paediatric cases / A. Pasini, C. Bracaglia, A. Aceti, M. Vivarelli, A. Lavacchini, A. Miniaci, F. De Benedetti, G. Montini. - In: RHEUMATOLOGY. - ISSN 1462-0324. - 53:8(2014 Aug), pp. 1409-1413. [10.1093/rheumatology/keu023]
Abstract:
OBJECTIVE:
To describe the diagnosis and management of renal disease in three paediatric cases of hypocomplementaemic urticarial vasculitis syndrome (HUVS).
METHODS:
Three children who were diagnosed with HUVS and developed abnormalities of renal function during the disease course are described.
RESULTS:
Urinary findings were heterogeneous: all the patients developed persistent microhaematuria, which was isolated in patient 1, associated with mild proteinuria in patient 2 and with nephrotic syndrome in patient 3. Renal biopsies were performed in all the patients: patients 1 and 2, who had normal levels of serum autoantibodies, shared a full-house IF (C3, C1q and Ig deposits), compatible with an SLE-like disease; patient 3 showed negative staining for IgG and IgM, but developed positive anti-dsDNA without fulfilling criteria for the diagnosis of SLE.
CONCLUSION:
Renal involvement in HUVS is probably more frequent and more severe than in adults and may appear later. Isolated microhaematuria can be the only sign of subclinical renal involvement: its role should not be underestimated and a renal biopsy should be considered. Previous observations of rapidly progressive nephritis and consequent end-stage renal disease in children suggest the need for prompt diagnosis and treatment of renal involvement.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
children; hypocomplementemic urticarial vasculitis syndrome; renal involvement
Elenco autori:
A. Pasini, C. Bracaglia, A. Aceti, M. Vivarelli, A. Lavacchini, A. Miniaci, F. De Benedetti, G. Montini
Link alla scheda completa: