Data di Pubblicazione:
2015
Citazione:
Plasma Citrulline : a New Marker of Gut Epithelium Alteration in Obese Patients? / S. Benedini, I. Fermo, A. Caumo, I. Terruzzi, L. Luzi. - In: JOURNAL OF DIABETES MELLITUS. - ISSN 2160-5831. - 5:4(2015 Nov), pp. 233-237. [10.4236/jdm.2015.54028]
Abstract:
Objectives: In the last decade gut microbial diversity was associated with the pathogenesis of obesity
in humans. Plasma citrulline was a simple and accurate biomarker for the severity of intestinal
failure and was associated with short bowel syndrome and alteration of gut permeability, being
developed as an alternative to D-xylose tolerance test for the diagnosis of an abnormal small
intestinal absorption of nutrients. This study was performed to ascertain whether obesity might
be associated with dysregulation of epithelial gut function. Methods: Fifteen obese individuals (5
M/10 F; BMI 37.4 ± 6.1 Kg/m2; 42 ± 6 yrs) and 15 healthy gender- and age-matched controls (6
M/9 F BMI: 22.7 ± 2.1 Kg/m2; 39 ± 7 yrs) underwent D-xylose load (25 g) and plasma citrulline,
plasma insulin, glucose and lipid profile testing. Results: Plasma citrulline was significantly lower
in the obese group (p = 0.045) with respect to controls, whilst total cholesterol, LDL and tryglicerides
concentration, insulin level and HOMA-IR were significantly higher in obese patients. In contrast,
after D-xylose load no difference in serum xylose was found between the two groups (p = ns).
Conclusions: Obese patients show a decreased citrulline concentration with respect to lean subjects.
Since citrulline is a known marker of intestinal health, alterations in the gut epithelium are likely
to be associated with the obesity syndrome. We propose to measure citrulline level in obese patients
on a routine basis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Citrulline; Obesity; HOMA-IR; Gut
Elenco autori:
S. Benedini, I. Fermo, A. Caumo, I. Terruzzi, L. Luzi
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