Data di Pubblicazione:
2015
Citazione:
Synthetic spirocyclic endoperoxides : new antimalarial scaffolds / M. Brindisi, S. Gemma, S. Kunjir, L. Di Cerbo, S. Brogi, S. Parapini, S. D'Alessandro, D. Taramelli, A. Habluetzel, S. Tapanelli, S. Lamponi, E. Novellino, G. Campiani, S. Butini. - In: MEDCHEMCOMM. - ISSN 2040-2503. - 6:2(2015), pp. 357-362. [10.1039/C4MD00454J]
Abstract:
Here we report the development of a straightforward synthetic procedure for the preparation of spirocyclic endoperoxides as synthetic analogues of the natural product dihydroplakortin. The peroxides presented here are more potent antiplasmodials than dihydroplakortin itself and we proved for the first time their antimalarial activity in vivo.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
plasmodium-falciparum; artemisinin; dihydroplakortin; peroxides; malaria; analogs
Elenco autori:
M. Brindisi, S. Gemma, S. Kunjir, L. Di Cerbo, S. Brogi, S. Parapini, S. D'Alessandro, D. Taramelli, A. Habluetzel, S. Tapanelli, S. Lamponi, E. Novellino, G. Campiani, S. Butini
Link alla scheda completa:
Link al Full Text: