Synthesis of aminocarbonyl N-Acylhydrazones by a three-component reaction of isocyanides, hydrazonoyl chlorides, and carboxylic acids
Articolo
Data di Pubblicazione:
2014
Citazione:
Synthesis of aminocarbonyl N-Acylhydrazones by a three-component reaction of isocyanides, hydrazonoyl chlorides, and carboxylic acids / M. Giustiniano, F. Meneghetti, V. Mercalli, M. Varese, F. Giustiniano, E. Novellino, G.C. Tron. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 16:20(2014 Oct 17), pp. 5332-5335. [10.1021/ol502515b]
Abstract:
A novel one-pot multicomponent synthesis of α-aminocarbonyl N-acylhydrazones starting from readily available hydrazonoyl chlorides, isocyanides, and carboxylic acids is reported. The strategy exploits the ability of the carboxylic acid as a third component to suppress all competing reactions between nitrile imines and isocyanides, channeling the course of the reaction toward the formation of this novel class of compounds. (Chemical Equation Presented).
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Giustiniano, F. Meneghetti, V. Mercalli, M. Varese, F. Giustiniano, E. Novellino, G.C. Tron
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