Data di Pubblicazione:
2000
Citazione:
Effects of iron on extracellular and intracellular growth of penicillium marneffei / D. Taramelli, S. Brambilla, G. Sala, A. Bruccoleri, C. Tognazioli, L. Riviera-Uzielli, J.R. Boelaert. - In: INFECTION AND IMMUNITY. - ISSN 0019-9567. - 68:3(2000 Mar), pp. 1724-1726. [10.1128/IAI.68.3.1724-1726.2000]
Abstract:
Killing of intracellular Penicillium marneffei conidia is demonstrated in gamma interferon-lipopolysaccharide-activated human THP1 and mouse J774 cells. Iron overload significantly reduces the antifungal activity of macrophages. Likewise, exogenous iron enhances and iron chelators inhibit the extracellular growth of P. marneffei. These results suggest that iron availability critically affects immunity to and the pathogenicity of P. marneffei.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
animals; deferoxamine; humans; interferon-gamma; iron; iron overload; lipopolysaccharides; mice; nitric oxide; penicillium
Elenco autori:
D. Taramelli, S. Brambilla, G. Sala, A. Bruccoleri, C. Tognazioli, L. Riviera Uzielli, J.R. Boelaert
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