Agmatine-containing poly(amidoamine)s as a novel class of antiviral macromolecules : structural properties and in vitro evaluation of infectivity inhibition
Articolo
Data di Pubblicazione:
2014
Citazione:
Agmatine-containing poly(amidoamine)s as a novel class of antiviral macromolecules : structural properties and in vitro evaluation of infectivity inhibition / M. Donalisio, E. Ranucci, V. Cagno, A. Civra, A. Manfredi, R. Cavalli, P. Ferruti, D. Lembo. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 58:10(2014), pp. 6314-6319. [10.1128/AAC.03420-14]
Abstract:
Poly(amidoamine)s (PAAs) are multifunctional tert-amine polymers endowed with high structural versatility. Here we report on the screening of a minilibrary of PAAs against a panel of viruses. The PAA AGMA1 showed antiviral activity against herpes simplex virus, human cytomegalovirus, human papillomavirus 16, and respiratory syncytial virus but not against human rotavirus and vesicular stomatitis virus. The results suggest the contribution of both a polycationic nature and side guanidine groups in imparting antiviral activity. Copyright
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Donalisio, E. Ranucci, V. Cagno, A. Civra, A. Manfredi, R. Cavalli, P. Ferruti, D. Lembo
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