Continuous flow asymmetric cyclopropanation reactions using Cu(i) complexes of Pc-L* ligands supported on silica as catalysts with carbon dioxide as a carrier
Articolo
Data di Pubblicazione:
2014
Citazione:
Continuous flow asymmetric cyclopropanation reactions using Cu(i) complexes of Pc-L* ligands supported on silica as catalysts with carbon dioxide as a carrier / B. Castano, E. Gallo, D.J. Cole-Hamilton, V. Dal Santo, R. Psaro, A. Caselli. - In: GREEN CHEMISTRY. - ISSN 1463-9262. - 16:6(2014), pp. 3202-3209. [Epub ahead of print] [10.1039/c4gc00119b]
Abstract:
Continuous flow heterogeneous asymmetric cyclopropanations catalysed by supported hydrogen-bonded (SHB) chiral copper(I) complexes of pyridine containing tetraazamacrocyclic ligands Pc-L* using CO2 as a transport vector are described. The catalytic system showed high stability and good recyclability without loss of activity for at least 24 h in CO2 and catalyst turn over numbers up to 440 were obtained with excellent conversion (up to 99%) and high selectivity (up to 88%). No leaching of copper was observed. Cyclopropane products from both aromatic and aliphatic olefins were obtained in good yields and enantiomeric excesses up to 72%.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
continous flow ; asymmetric sunthesis ; carbon dioxide ; copper complexes ; cyclopropanation ; supported catalysts
Elenco autori:
B. Castano, E. Gallo, D.J. Cole Hamilton, V. Dal Santo, R. Psaro, A. Caselli
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