Staphylococcus aureus virulence factors in evasion from innate immune defenses in human and animal diseases
Articolo
Data di Pubblicazione:
2013
Citazione:
Staphylococcus aureus virulence factors in evasion from innate immune defenses in human and animal diseases / A. Zecconi, F. Scali. - In: IMMUNOLOGY LETTERS. - ISSN 0165-2478. - 150:1-2(2013 Feb), pp. 12-22. [10.1016/j.imlet.2013.01.004]
Abstract:
In the last decades, Staphylococcus aureus acquired a dramatic relevance in human and veterinary
medicine for different reasons, one of them represented by the increasing prevalence of antibiotic resistant
strains. However, antibiotic resistance is not the only weapon in the arsenal of S. aureus. Indeed,
these bacteria have plenty of virulence factors, including a vast ability to evade host immune defenses.
The innate immune system represents the first line of defense against invading pathogens. This system
consists of three major effector mechanisms: antimicrobial peptides and enzymes, the complement
system and phagocytes. In this review, we focused on S. aureus virulence factors involved in the immune
evasion in the first phases of infection: TLR recognition avoidance, adhesins affecting immune response
and resistance to host defenses peptides and polypeptides.
Studies of innate immune defenses and their role against S. aureus are important in human and veterinary
medicine given the problems related to S. aureus antimicrobial resistance. Moreover, due to
the pathogen ability to manipulate the immune response, these data are needed to develop efficacious
vaccines or molecules against S. aureus
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adhesins; Host defense peptides; Innate immunity; Staphylococcus aureus; TLR
Elenco autori:
A. Zecconi, F. Scali
Link alla scheda completa: