Data di Pubblicazione:
1992
Citazione:
Ocular pharmacokinetics of rufloxacin a new fluoroquinolone antibiotic / P. Nucci, N. Lombardo, F. Cremonesi, M.P. Manitto, R. Brancato, M. Ghione. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - 140:6(1992 Jun), pp. 563-7-567.
Abstract:
Ocular pharmacokinetics of rufloxacin (MF 934), a new monofluorinated quinolone derivative, has been investigated in rabbits. A long half-life, good g.i. absorption and a higher tissue/plasma concentration than that of other quinolones, are its interesting pharmacokinetic properties. However, there is reason to believe that drug accumulation may occur in deep body compartments. We determined plasma, aqueous, and vitreous concentrations of the drug at 1, 4, 8, and 24h after a single 50 mg/kg i.v. administration of rufloxacin. Our data show that rufloxacin, administered by the i.v. route, rapidly reaches chemotherapeutically useful levels in aqueous and vitreous fluids. Although still present in plasma 8 hours after administration, it proved to be undetectable in ocular fluids, signifying that the depletion of the deep compartments occurs well in advance of the next invasion. Due to its antibacterial effectiveness and pharmacokinetic properties rufloxacin may take a relevant place among the quinolone derivatives in the treatment of ocular infections.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Vitreous Body; Animals; Anti-Infective Agents; Injections, Intravenous; Half-Life; Eye; Aqueous Humor; Fluoroquinolones; Quinolones; Rabbits; Tissue Distribution; Time Factors
Elenco autori:
P. Nucci, N. Lombardo, F. Cremonesi, M.P. Manitto, R. Brancato, M. Ghione
Link alla scheda completa: