Differential translocation of protein kinase C isozymes in rats characterized by a chronic lack of LTP induction and cognitive impairment
Articolo
Data di Pubblicazione:
1996
Citazione:
Differential translocation of protein kinase C isozymes in rats characterized by a chronic lack of LTP induction and cognitive impairment / A. Caputi, S. Rurale, L. Pastorino, M. Cimino, F. Cattabeni, M.M.G. Di Luca. - In: FEBS LETTERS. - ISSN 0014-5793. - 393:1(1996), pp. 121-123. [10.1016/0014-5793(96)00846-0]
Abstract:
The translocation of protein kinase C isozymes was investigated in an animal model of cognitive deficit and lack of induction of long-term potentiation (LTP). In MAM rats, presynaptic α, β, ε PKC showed enhanced translocation, while postsynaptic γ PKC displayed decreased translocation when compared to control levels. This imbalance of PKC isozyme translocation between the pre- and post-synaptic compartment might therefore represent a possible molecular cause for the lack of synaptic plasticity observed in these animals.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Protein kinase C; Synaptic plasticity; Translocation
Elenco autori:
A. Caputi, S. Rurale, L. Pastorino, M. Cimino, F. Cattabeni, M.M.G. Di Luca
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