ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: Evidence from a peripheral model
Articolo
Data di Pubblicazione:
2002
Citazione:
ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: Evidence from a peripheral model / B. Borroni, F. Colciaghi, L. Pastorino, S. Archetti, P. Corsini, F. Cattabeni, M.M.G. Di Luca, A. Padovani. - In: EUROPEAN NEUROPSYCHOPHARMACOLOGY. - ISSN 0924-977X. - 12:3(2002), pp. 195-200.
Abstract:
Three major amyloid precursor protein (APP) forms with apparent molecular weight ranging from 106 to 130 kDa are present in human platelets. Alzheimer disease (AD) is associated with a decreased APP forms ratio (APPr) between the three major forms. A total of 25 mild to moderate AD patients were investigated. Platelet APPr was studied before and after 30 days of acetylcholinesterase-inhibitor treatment (donepezil, 5 mg daily). Patients were grouped into non-ε4 carriers and ε4 carriers according to apolipoprotein E (ApoE) genotype. At baseline, all patients showed low APPr levels and no significant difference was found between the two ApoE subgroups. After treatment, although a marked improvement in APPr was observed in most patients, non-ε4 carriers displayed a higher increase compared to ε4 carriers (P<0.0001). The present study provides evidence that donepezil influences APP metabolism in platelets, and suggests that ApoE genotype might be an important modulating factor for drug responsiveness in AD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alzheimer disease; Amyloid precursor protein (APP); Apolipoprotein E; Donepezil
Elenco autori:
B. Borroni, F. Colciaghi, L. Pastorino, S. Archetti, P. Corsini, F. Cattabeni, M.M.G. Di Luca, A. Padovani
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