Peripheral blood abnormalities in Alzheimer disease: Evidence for early endothelial dysfunction
Articolo
Data di Pubblicazione:
2002
Citazione:
Peripheral blood abnormalities in Alzheimer disease: Evidence for early endothelial dysfunction / B. Borroni, R. Volpi, G. Martini, R. Del Bono, S. Archetti, F. Colciaghi, N. Maalikjy Akkawi, M.M.G. Di Luca, G. Romanelli, L. Caimi, A. Padovani. - In: ALZHEIMER DISEASE & ASSOCIATED DISORDERS. - ISSN 0893-0341. - 16:3(2002), pp. 150-155.
Abstract:
Clinical and epidemiologic studies demonstrate that vascular risk factors may be involved in Alzheimer disease (AD). To evaluate whether vascular abnormalities are an early feature of AD, several parameters of coagulation and fibrinolysis were assessed. Thirty patients with mild AD and 30 age-matched control subjects entered the study. All subjects performed a standardized clinical and laboratory protocol. Persons with vascular risk factors and systemic diseases were excluded. AD patients present significant increased levels of thrombomodulin (p < 0.0001) and sE-selectin (p < 0.03). In contrast, no difference was found between the two diagnostic groups in the levels of β-thromboglobulin, prothrombin fragment 1+2, fibrinogen, and von Willebrand factor. No other association but diagnosis was found with thrombomodulin and sE-selectin. These findings suggest that endothelial dysfunction is an early event in AD patients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alzheimer disease; Endothelial dysfunction; Hemostasis changes
Elenco autori:
B. Borroni, R. Volpi, G. Martini, R. Del Bono, S. Archetti, F. Colciaghi, N. Maalikjy Akkawi, M.M.G. Di Luca, G. Romanelli, L. Caimi, A. Padovani
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