Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals
Articolo
Data di Pubblicazione:
2011
Citazione:
Under representation of the inhibitory KIR3DL1 molecule and the KIR3DL1+/BW4+ complex in HIV exposed seronegative individuals / F.R. Guerini, S. Lo Caputo, A. Gori, A. Bandera, F. Mazzotta, A. Uglietti, M. Zanzottera, R. Maserati, M.S. Clerici. - In: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. - ISSN 1201-9712. - 203:9(2011 May), pp. 1235-1239. [10.1093/infdis/jir020]
Abstract:
The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK cells in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals by means of molecular typing of HLA B, Cw, and killer cell immunoglobulin-like receptor (KIR) molecules. In HESN individuals, compared with HIV patients, the frequency of the inhibitory KIR3DL1 allele and of the KIR3DL1(+)/Bw4(+) inhibitory complex was reduced, whereas that of the activatory KIR3DS1(+) ligand and the activatory Bw4(+)/3DL1(-)/3DS1(+) complex was increased, resulting in a statistically significant diversion from Hardy-Weinberg equilibrium (KIR3DS1 homozygote) in HESN individuals. The reciprocal equilibrium between inhibitory and activatory NK receptors and their ligands favors NK activation in HESN individuals.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F.R. Guerini, S. Lo Caputo, A. Gori, A. Bandera, F. Mazzotta, A. Uglietti, M. Zanzottera, R. Maserati, M.S. Clerici
Link alla scheda completa: