Le ricerche sull’acido solfidrico (H2S) nella prospettiva di nuovi interventi farmacologici
Articolo
Data di Pubblicazione:
2009
Citazione:
Le ricerche sull’acido solfidrico (H2S) nella prospettiva di nuovi interventi farmacologici / A. Pecile, F. Berti, G. Rossoni. - In: GERIATRIC & MEDICAL INTELLIGENCE. - ISSN 1121-8460. - 18:1(2009), pp. 47-54.
Abstract:
Hydrogen sulphide (H2S) is gaseous transmitter that the results of an intensive research
of these last years adduces good reason for its role in different pathophysiological processes. The
generation of H2S takes place in various mammalian cells from L-cysteine primarily via two key enzymes,
cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS). The organ specific expression
regulation of both CSE and CBS has been defined, and evidence is accumulating to demonstrate
that inhibitors of H2S or therapeutic H2S-donors exert significant effects in various animal models of
inflammation, reperfusion injury, gastric mucosal blood flow regulation, and many other. This article
has the aim to describe the biofunctional properties of H2S and to prospect the potential therapeutic
implications of this mediator principally in inflammation and cardiovascular pathology
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
hydrogen sulphide ; inflammation ; hypertension ; reperfusion-damage
Elenco autori:
A. Pecile, F. Berti, G. Rossoni
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