Effects of Melatonin on Exercise-Induced Oxidative Stress in Adults with Obesity Undergoing a Multidisciplinary Body Weight Reduction Program
Articolo
Data di Pubblicazione:
2024
Citazione:
Effects of Melatonin on Exercise-Induced Oxidative Stress in Adults with Obesity Undergoing a Multidisciplinary Body Weight Reduction Program / A.E. Rigamonti, F.M. Rubino, D. Caroli, A. Bondesan, S. Mai, S.G. Cella, L. Centofanti, R. Paroni, A. Sartorio. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 13:17(2024), pp. 5216.1-5216.17. [10.3390/jcm13175216]
Abstract:
ackground: Obesity is characterized by increased oxidative stress, which, in a vicious
circle, promotes chronic low-grade inflammation. Melatonin, a well-documented antioxidant, might
be useful as a supplement to enhance the cardiometabolic benefits of any body weight reduction
program (BWRP). Objectives/Methods: The present study aimed to evaluate the post-exercise
oxidative stress and inflammation in a group of subjects with obesity treated with melatonin
(2 mg/die) or placebo, undergoing a 2-week BWRP, with the administration of a single bout of
acute exercise at the start and the end of the protocol (G1–G15). Results: Eighteen adults with obesity
were enrolled and distributed to the two arms of the study: the melatonin group (F/M: 7/2; age:
27.8 ± 5.6 years; body mass index [BMI]: 43.0 ± 4.9 kg/m2) and the placebo group (F/M: 6/3; age:
28.8 ± 5.0 years; BMI: 42.8 ± 4.0 kg/m2). BWRP induced a decrease in BMI and waist circumference
(WC) in both groups; plasma glucose, blood glycated hemoglobin (HbA1c), and neutrophil to lympho-
cyte ratio (NLR) were reduced only in the placebo group. Importantly, plasma biological antioxidant
potential (BAP) increased throughout BWRP. Paradoxically, melatonin enhanced post-exercise produc-
tion of plasma derivatives of reactive oxygen metabolites (d-ROMs) and erythrocytic glutathionyl-Hb
(HbSSG) (at G1 and G15). Finally, differently from the placebo group, melatonin-treated subjects
did not exhibit the BWRP-induced decrease in plasma levels of interleukin-6 (IL-6), before and after
exercise, at the end of two weeks (G15). Conclusions: Melatonin is presumably an antioxidant with
“conditional” prooxidant actions. The use of melatonin as a supplement in subjects with obesity
might be deleterious due to the abolishment of BWRP-induced cardiometabolic benefits.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
obesity; melatonin; oxidative stress; inflammation; body weight reduction program; exercise
Elenco autori:
A.E. Rigamonti, F.M. Rubino, D. Caroli, A. Bondesan, S. Mai, S.G. Cella, L. Centofanti, R. Paroni, A. Sartorio
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