Electrochemically-assisted deposition on TiO2 scaffold for tissue engineering : an apatite bio-inspired crystallization pathway
Articolo
Data di Pubblicazione:
2011
Citazione:
Electrochemically-assisted deposition on TiO2 scaffold for tissue engineering : an apatite bio-inspired crystallization pathway / A. Naldoni, A. Minguzzi, A. Vertova, V. Dal Santo, L. Borgese, C.L. Bianchi. - In: JOURNAL OF MATERIALS CHEMISTRY. - ISSN 0959-9428. - 21:2(2011 Jan), pp. 400-407. [10.1039/C0JM02446E]
Abstract:
The interactions among inorganic materials and biological environments occurring at the nanoscale level are crucial to understand the mechanisms behind the bioactivity of biomaterials and for their better design. In the present study, we prepare TiO2 and TiO2/hydroxyapatite (HA) scaffolds for Tissue
Engineering (TE) via a sol–gel/polymeric spongemethod. The obtained architectures have a biomimetic morphology (trabecular bone) and an average pore dimension of 100 mm. Moreover, we introduce a versatile electrochemically assisted deposition method for non-conductive substrates that allows the
formation of a stable coating on the pore walls of the scaffolds with the morphology and phase composition determined by SEM and DRIFTS. Both the materials properties are strictly correlated to the scaffold composition: pure TiO2 scaffolds are coated with amorphous calcium carbonate while onto
TiO2/HA scaffolds we observe the growth of octacalcium phosphate nanocrystals. The bioactivity of the TiO2-based scaffolds is then predicted examining the apatite formation on their surface in simulated
body fluid. The presence of apatite crystals is observed only for pure TiO2 scaffolds due to the transformation of amorphous calcium carbonate into crystalline biomimetic HA: a novel bio-inspired crystallization pathway toward the bioactivity of scaffold for TE.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Naldoni, A. Minguzzi, A. Vertova, V. Dal Santo, L. Borgese, C.L. Bianchi
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