A pilot study to assess the effects of combining fluticasone propionate/ salmeterol and tiotropium on the airflow obstruction of patients with severe-to-very severe COPD
Articolo
Data di Pubblicazione:
2007
Citazione:
A pilot study to assess the effects of combining fluticasone propionate/
salmeterol and tiotropium on the airflow obstruction of patients with
severe-to-very severe COPD / M. Cazzola, F. Andò, P. Santus, P. Ruggeri, F. Di Marco, A. Sanduzzi, M. D’Amato. - In: PULMONARY PHARMACOLOGY & THERAPEUTICS. - ISSN 1094-5539. - 20:5(2007), pp. 556-561. [10.1016/j.pupt.2006.06.001]
Abstract:
The aim of this pilot study was to explore the relative efficacy in terms of improvement in symptoms and lung function of combining
fluticasone propionate/salmeterol combination (FSC) and tiotropium in patients with severe-to-very severe stable COPD. Ninety
patients were randomized to receive 3 months of treatment in one of three treatment groups: (1) FSC 500/50 mg Diskus, 1 inhalation twice
daily+placebo Handihaler 1 inhalation once-daily daily; (2) tiotropium 18 mg Handihaler, 1 inhalation once daily+placebo Diskus, 1
inhalation twice daily; (3) FSC 500/50 mg Diskus, 1 inhalation twice daily+tiotropium 18 mg Handihaler, 1 inhalation once-daily daily.
Patients attended the clinic before and after 1 month, 2 months, and 3 months of treatment for evaluations of pulmonary function, and
dyspnea, which was assessed using a visual analog scale (VAS). Also the supplemental salbutamol use was measured. Eighty-one patients
completed the 3-month treatment period: 26 patients receiving FSC, 26 patients receiving tiotropium, and 29 patients receiving
FSC+tiotropium. Patients were withdrawn for COPD exacerbation. Improvements in trough FEV1 with all treatments medications
were observed by the first month when trough FEV1 had improved significantly above baseline by 74mL ðpo0:05Þ in the tiotropium
group, by 117mL ðpo0:05Þ in the FSC group and by 115mL ðpo0:05Þ in FSC+tiotropium group. At the end of the study, trough FEV1
had improved significantly above baseline by141mL ðpo0:05Þ in the tiotropium group, by 140mL ðpo0:05Þ in the FSC group and by
186mL ðpo0:05Þ in FSC+tiotropium group. The difference between FSC and tiotropium appeared to decrease, that between FSC and
FSC+tiotropium appeared to increase and that between tiotropium and FSC+tiotropium remained almost similar with study duration.
Our results suggest that adding FSC and tiotropium may provide benefits in symptomatic patients with severe-to-very severe stable
COPD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Salmeterol ; Fluticasone propionate ; Combination therapy ; Tiotropium ; COPD ; Dyspnea ; Lung function
Elenco autori:
M. Cazzola, F. Andò, P. Santus, P. Ruggeri, F. Di Marco, A. Sanduzzi, M. D’Amato
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