Onset of action of formoterol/budesonide in single inhaler vs. formoterol in patients with COPD
Articolo
Data di Pubblicazione:
2004
Citazione:
Onset of action of formoterol/budesonide in single inhaler vs. formoterol
in patients with COPD / M. Cazzola, P. Santus, F. Di Marco, P. Carlucci, M. Mondoni, M.G. Matera, S. Centanni. - In: PULMONARY PHARMACOLOGY & THERAPEUTICS. - ISSN 1094-5539. - 17:3(2004), pp. 121-125. [10.1016/j.pupt.2004.01.001]
Abstract:
Formoterol is a b2-agonist bronchodilator that combines a fast onset of action with a long duration of broncholytic effect. An increasing
documentation is showing that the combination of a long acting b2-adrenoceptor agonist bronchodilator and an inhaled corticosteroid targets
the airways obstruction in patients with COPD. In this study, we have explored whether the acute addition of an inhaled corticosteroid
influences the fast bronchodilator response to formoterol. A total of 20 patients with stable COPD were randomized. Single doses of
formoterol/budesonide 2 £ (4.5/160) mg or formoterol 2 £ 4.5 mg were given via Turbuhaler. Serial measurements of FEV1 were performed
over 60 min. Formoterol/budesonide elicited a significantly larger mean FEV1-AUC0 – 15 min than formoterol alone. Also the change in FEV1
15 min after inhalation of formoterol/budesonide combination (0.197 l; 95% CI: to 0.142–0.252) was greater than that induced by formoterol
alone (0.147 l; 95% CI: to 0.092–0.201). The mean increases in FEV1 were always higher after budesonide/formoterol than formoterol
alone, although both treatments induced a significant improvement over baseline at each explored time point. Even the FEV1-AUC0 – 60 min
after formoterol/budesonide was significantly larger than that after formoterol. Both treatments induced a significant reduction in VAS score
but did not modify heart rate in a statistically significant manner. This study indicates that the addition of budesonide influences the fast onset
of action of formoterol, but does not induce systemic effects, in patients with stable COPD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chronic obstructive pulmonary disease; Formoterol; Formoterol/budesonide combination; Onset of action
Elenco autori:
M. Cazzola, P. Santus, F. Di Marco, P. Carlucci, M. Mondoni, M.G. Matera, S. Centanni
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