The degree of engagement of cardiac and sympathetic arms of the baroreflex does not depend on the absolute value and sign of arterial pressure variations
Articolo
Data di Pubblicazione:
2023
Citazione:
The degree of engagement of cardiac and sympathetic arms of the baroreflex does not depend on the absolute value and sign of arterial pressure variations / B. De Maria, L.A. Dalla Vecchia, V. Bari, B. Cairo, F. Gelpi, F. Perego, A.C.M. Takahashi, J.C. Milan-Mattos, V. Minatel, P. Rehder-Santos, M. Esler, E. Lambert, M. Baumert, A.M. Catai, A. Porta. - In: PHYSIOLOGICAL MEASUREMENT. - ISSN 0967-3334. - 44:11(2023), pp. 114002.1-114002.14. [10.1088/1361-6579/ad0976]
Abstract:
Objective. The percentages of cardiac and sympathetic baroreflex patterns detected via baroreflex
sequence (SEQ) technique from spontaneous variability of heart period (HP) and systolic arterial
pressure (SAP) and of muscle nerve sympathetic activity (MSNA) burst rate and diastolic arterial
pressure (DAP) are utilized to assess the level of the baroreflex engagement. The cardiac baroreflex
patterns can be distinguished in those featuring both HP and SAP increases (cSEQ++) and decreases
(cSEQ−−), while the sympathetic baroreflex patterns in those featuring a MSNA burst rate decrease
and a DAP increase (sSEQ+−) and vice versa (sSEQ−+). The present study aims to assess the
modifications of the involvement of the cardiac and sympathetic arms of the baroreflex with age and
postural stimulus intensity. Approach. We monitored the percentages of cSEQ++ (%cSEQ++) and
cSEQ−− (%cSEQ−−) in 100 healthy subjects (age: 21–70 years, 54 males, 46 females), divided into
five sex-balanced groups consisting of 20 subjects in each decade at rest in supine position and during
active standing (STAND). We evaluated %cSEQ++, %cSEQ−−, and the percentages of sSEQ+− (%
sSEQ+−) and sSEQ−+ (%sSEQ−+) in 12 young healthy subjects (age 23 ± 2 years, 3 females, 9
males) undergoing incremental head-up tilt. Main results. We found that: (i) %cSEQ++ and %cSEQ
−− decreased with age and increased with STAND and postural stimulus intensity; (ii) %sSEQ+−
and %sSEQ−+ augmented with postural challenge magnitude; (iii) the level of cardiac and
sympathetic baroreflex engagement did not depend on either the absolute value of arterial pressure or
the direction of its changes. Significance. This study stresses the limited ability of the cardiac and
sympathetic arms of the baroreflex in controlling absolute arterial pressure values and the equivalent
ability of both positive and negative arterial pressure changes in soliciting them.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
active standing; aging; baroreflex sequence analysis; blood pressure; heart rate variability; incremental head-up tilt; muscle nerve sympathetic activity
Elenco autori:
B. De Maria, L.A. Dalla Vecchia, V. Bari, B. Cairo, F. Gelpi, F. Perego, A.C.M. Takahashi, J.C. Milan-Mattos, V. Minatel, P. Rehder-Santos, M. Esler, E. Lambert, M. Baumert, A.M. Catai, A. Porta
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