Evaluation of cardiovascular and cerebrovascular control mechanisms in postural orthostatic tachycardia syndrome via conditional transfer entropy: the impact of the respiratory signal type
Articolo
Data di Pubblicazione:
2023
Citazione:
Evaluation of cardiovascular and cerebrovascular control mechanisms in postural orthostatic tachycardia syndrome via conditional transfer entropy: the impact of the respiratory signal type / F. Gelpi, V. Bari, B. Cairo, B. De Maria, R. Wells, M. Baumert, A. Porta. - In: PHYSIOLOGICAL MEASUREMENT. - ISSN 0967-3334. - 44:(2023), pp. 064001.1-064001.17. [10.1088/1361-6579/acdb47]
Abstract:
Objective. Closed loop cardiovascular (CV) and cerebrovascular (CBV) variability interactions are
assessed via transfer entropy (TE) from systolic arterial pressure (SAP) to heart period (HP) and
vice versa and from mean arterial pressure (MAP) to mean cerebral blood velocity (MCBv) and
vice versa. This analysis is exploited to assess the efficiency of baroreflex and cerebral autoregulation.
This study aims at characterizing CV and CBV controls in postural orthostatic tachycardiac syndrome
(POTS) subjects experiencing exaggerated sympathetic response during orthostatic challenge via
unconditional TE and TE conditioned on respiratory activity (R). Approach. In 18 healthy controls
(age: 28 ± 13 yrs; 5 males, 13 females) and 15 POTS individuals (age: 29 ± 11 yrs; 3 males, 12 females)
we acquired beat-to-beat variability of HP, SAP, MAP and MCBv and two R signals, namely
respiratory chest movement (RCM) and capnogram (CAP). Recordings were made at sitting rest and
during active standing (STAND). TE was computed via vector autoregressive approach. Main results.
We found that: (i) when assessing CV interactions, the increase of the TE from SAP to HP during
STAND, indicating baroreflex activation, is detected solely when conditioning on RCM; (ii) when
assessing CBV interactions, the impact of R on the TE computation is negligible; (iii) POTS shows
baroreflex impairment during STAND; (iv) POTS exhibits a normal CBV response to STAND.
Significance. TE is useful for detecting the impairment of specific regulatory mechanisms in POTS.
Moreover, using different R signals highlights the sensitivity of CV and CBV controls to specific R
aspects.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
active standing; autonomic nervous system; baroreflex; cerebral autoregulation; cerebral blood flow; heart rate variability; vector autoregresssive model
Elenco autori:
F. Gelpi, V. Bari, B. Cairo, B. De Maria, R. Wells, M. Baumert, A. Porta
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