Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral)
Articolo
Data di Pubblicazione:
2023
Citazione:
Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral) / G. Damiani, I. Controne, H. Al-Shakhshir, P.D.M. Pigatto. - In: BIOMEDICINES. - ISSN 2227-9059. - 11:4(2023), pp. 1036.1-1036.11. [10.3390/biomedicines11041036]
Abstract:
Despite the well-known cutaneous beneficial effect of thermal water on the skin, no data exist regarding the potential biological effect of orally consumed water on healthy skin. Thus, in this single-center, double-blind, randomized controlled clinical trial conducted on age and menstrual cycle timing-matched healthy female volunteers (24 + 24) consuming water A (oligo-mineral) or water B (medium-mineral) for 1 month (T1), the cutaneous lipidomics were compared. Interestingly, only water A consumers had a statistically significant (p < 0.001) change in cutaneous lipidomics, with 66 lipids different (8 decreased and 58 increased). The cutaneous lipidomics of consumers of water A vs. water B were statistically different (p < 0.05). Twenty cutaneous lipids were necessary to predict the water type previously consumed (AUC ~70). Our study suggests that drinking oligo-mineral water may change skin biology and may influence the cutaneous barrier, so future dermatological clinical trials should also account for the water type consumed to avoid potential confounders.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
lipidomics; medium-mineral water; oligo-mineral water; precision medicine; skin; waters
Elenco autori:
G. Damiani, I. Controne, H. Al-Shakhshir, P.D.M. Pigatto
Link alla scheda completa: